Priv.-Doz. Dr. med. Roman-Ulrich Müller
Department II of Internal Medicine
University Hospital Cologne
Kerpener Str. 62
50937 Cologne, Germany
+49 221 478-30627
roman-ulrich.mueller@uk-koeln.de
Prof. Dr. Christoph Dieterich
Section of Bioinformatics and Systems Cardiology Department of Internal Medicine III
University Hospital Heidelberg
Im Neuenheimer Feld 669
69120 Heidelberg, Germany
+49 6221 56-36884
christoph.dieterich@med.uni-heidelberg.de

Addresses of the institutions:

University Hospital of Cologne
NRW-Nachwuchsgruppe “RNA-biology in kidney disease”
CECAD Research Center, 3. OG
Joseph-Stelzmann-Str. 26
50931 Cologne, Germany
Section of Bioinformatics and Systems Cardiology
Department of Internal Medicine III
University Hospital Heidelberg
Im Neuenheimer Feld 669
69120 Heidelberg, Germany

Research project 5

Non-coding RNAs in podocyte disorders – taking glomerular disease beyond the coding genome

Roman Müller and Christoph Dieterich

Non-coding RNAs have been linked to various diseases including focal segmental glomerulosclerosis (FSGS). The revolution in sequencing technology has opened up entirely new opportunities regarding the discovery of novel transcripts. It is now widely agreed that around 80% of the human genome is transcribed in a cell-type and context-specific manner. The vast majority of all transcripts lacks any protein coding potential. Among these non-coding transcripts, the novel class of long non-coding RNAs (lncRNAs) has gained major attention due to an increasing number of studies showing its importance in organ development and disease. However, how this occurs on the molecular level and how lncRNAs impact on organ function and disease has – albeit few exceptions – remained elusive with virtually no data at all regarding FSGS. We are studying the role of lncRNAs in FSGS to exploit the great potential of this emerging field for identifying novel diagnostic and therapeutic targets.